The Nostrade family is a Mafia family headed by Light Nostrade and, according to Dalzollene, is part of the Ritz family. It was originally an insignificant small-town Mafia family but by taking advantage of his daughter's divination, Light was able to gain favor with high-level Mafia capos and even the Ten Dons to rise through the ranks, turning it into a powerful family.
- Light Nostrade: Head of the family, an ambitious, canny man who strives to climb to the top of the Mafia by using his daughter's ability.
- Neon Nostrade: Light's spoiled teenage daughter, who likes to collect rare body parts and has the ability to predict future. She does not know anything about her family's business.
Fearing that the people he has supplanted along the way will retaliate by attacking his daughter, Light has hired a number of bodyguards to protect her. They include, but not limited to, the following:
- Dalzollene: Former head bodyguard. He was the only bodyguard who had direct contact with Light and was in charge of recruiting new bodyguards for Neon. On September 1st 2000, he was killed by Phinks of the Phantom Troupe.
- Kurapika: Current head bodyguard and one of the new members of the team. His true intention is to make use of Light's and Neon's connections to track down the collectors of the Scarlet Eyes and eliminate them all.
- Melody: One of the new bodyguards and a Music Hunter, trusted by Kurapika. She has a highly developed sense of hearing and can tell someone's feelings by listening to their heartbeat.
- Basho: One of the new bodyguards and a professional Hunter from Jappon. The contents of the haikus he composes will become true.
- Linsen: A professional Hunter who was employed earlier than Kurapika. He is still alive but not much is known about him.
- Baise: One of the new bodyguards and a Manipulator who could turn anyone she kissed into her slave for 3 hours. She was killed by Shizuku of the Phantom Troupe when attending the Mafia's underground auction on September 1st.
- Ivlenkov: One of the older members of the team. He was killed by Shizuku when attending the Mafia's underground auction on September 1st.
- Shachmono Tocino: One of the older members of the team and a professional Hunter. He was killed by Franklin of the Phantom Troupe when attending the Mafia's underground auction on September 1st.
- Squala: One of the older members of the team and Eliza's boyfriend. He was not a pro-Hunter but had the ability to manipulate dogs. He was beheaded by Nobunaga of the Troupe in the evening of September 4th.
- Eliza: Squala's lover and one of Neon's attendants. She was devastated when she knew Squala was dead.
- The name of the family may be a reference to the Sicilian name of the Mafia, Cosa Nostra.
- It may also be a reference to Nostradamus, the famous French seer.